Description:
COMPOSITION
1 tablet of Primobolic contains metenolone acetate (17beta-hydroxy-1-methyl-5alpha-androst-1-en-3-one acetate) 50 mg.
PHARMACOLOGICAL ACTION
In aplastic anaemias of various origins - both the idiopathic forms and those with exogenously damaged bone marrow - high doses of metenolone acetate may stimulate bone marrow function, particularly erythropoiesis. Metenolone acetate is a non-17alpha-alkylated medicine.
INDICATIONS
Aplastic anaemias.
CONTRA-INDICATIONS
Primobolic is contra-indicated in pregnancy as the metenolone acetate contained in the preparation, like all agents, possesses some androgenic activity which may lead to signs of virilisation in the female newborn.
Because of this androgenic activity, Primobolic is also contra-indicated in patients with prostatic carcinoma, since such substances may aggravate the disease.
DOSAGE AND DIRECTIONS FOR USE
The therapy may have to be continued for at least 3 months at a dosage of 2-3mg/kg bodyweight per day, ie 4-6 tablets for a person weighing 50 kg. Since some patients only respond after several months, treatment must not be stopped too soon. After improvement of the clinical picture treatment should, as a general rule, be continued for a further few weeks. Deterioration of the blood count after discontinuation of therapy may be reversed by renewed administration of Primobolan S.
Category
Primobolan Depot
Side effects:
In female patients, signs of virilisation (acne, hirsutism, hoarseness, possibly irreversible deepening of the voice) must be reckoned with; in sexually mature women menstrual irregularities may occur.
In adult males, spermatogenesis may be inhibited, in boys there may be signs of premature puberty.
Non-adult patients should be monitored for accelerated bone maturation by X-ray.
Impairment of liver function is less frequent than with a 17alpha-alkylated medicines.
In men, regular examinations of the prostate should be carried out prophylactically to exclude a malignant tumour.
Dose:
The dose of these medicines will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose:
If you miss a dose of this medicine and your dosing schedule is:
* One dose a day?Take the missed dose as soon as possible. However, if you do not remember it until the next day, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
* More than one dose a day?Take the missed dose as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
If you have any questions about this, check with your doctor.
